The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion

Abstract Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of invasiveness and high metastatic potential.Epithelial-mesenchymal transition (EMT) is a prerequisite for cancer cell little giant chick brooder kit invasion and spread, and it is mediated by the specific cellular behaviors and the tumor microenvironment.Autophagy has long been a target of cancer therapy, and it has been considered to play a dual and contradictory role, particularly regarding EMT-mediated PDAC invasion.This review discusses the characteristics and the biological role of EMT and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of luhta henttola providing novel insights into targeting EMT and autophagy to overcome PDAC invasion.